September 4, 1806
They arrived at the grave of Sergeant Charles Floyd. It had been disturbed and left only half covered. They completely covered the grave before moving on. On the 6th September they met another trader. They purchased a gallon of whiskey and gave a dram to each man. On 9th September William Clark wrote in his journal that Meriwether Lewis had made a complete recovery from his wound, and that the expedition members were becoming increasingly anxious to get to their country and friends.

The expedition passed several more traders including Joseph Gravelines who had previously acted as interpreter and had been sent back to President Jefferson with an Arikara Chief. Unfortunately the Chief had died while in Washington, and Gravelines was returning to the Arikaras with a speech and some gifts from the President. He had also been instructed to enquire about Lewis and Clark.

To their great relief, the Corps of Discovery were no longer plagued by the mosqitoes that had been so abundant in the upper parts of the rivers.

September 17, 1806
Lewis and Clark met with a Robert McClellan on the 12th September and a John McClellan on the 17th. One of these men informed them that the American public had given them up for dead and that they were all but forgotten, although the President had not yet given up hope. Sergeant Ordway recorded in his journal on the 12th that it was Robert McClellan, while William Clark recorded in his journal on the 17th that it was John McClellan.

September 21, 1806
The party arrived at St. Charles, Missouri. They were met by a large number of the inhabitants who were delighted to see them. They were invited to the homes of several of the people.

September 23, 1806
The Corps of Discovery finally landed in St. Louis, Missouri having been gone for 2 years, 4 months and 10 days.